Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective impairments in managerial knowledge following pre-frontal cortex damage

A Sirigu1, T Zalla, B Pillon

  • 1I.N.S.E.R.M. Unité 289, Hôpital de la Salpétrière, Paris, France.

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
|June 1, 1995
PubMed
Summary

Patients with prefrontal cortex lesions show impaired script generation, affecting action sequencing and planning. This suggests a specific deficit in managerial knowledge due to frontal lobe damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor-stroma proportion on primary tumor as a prognostic biomarker in advanced ovarian cancer patients receiving chemo-immunotherapy as first-line therapy: analyses from the NeoPembrOV/GINECO phase II randomized trial.

ESMO open·2025
Same author

Diagnostic and prognostic yields of ambulatory blood pressure measurements in haemodialysis patients: a 6-year longitudinal study.

Acta cardiologica·2024
Same author

The pattern of cortical thickness associated with executive dysfunction in MCI and SCC: The MEMENTO cohort.

Revue neurologique·2024
Same author

"Time Saved" Calculations to Improve Decision-Making in Progressive Disease Studies.

The journal of prevention of Alzheimer's disease·2024
Same author

Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical Trials.

The journal of prevention of Alzheimer's disease..·2024
Same author

T1w/FLAIR ratio standardization as a myelin marker in MS patients.

NeuroImage. Clinical·2022

Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Script generation is crucial for daily functioning.
  • Understanding the neural basis of script processing aids in diagnosing cognitive deficits.

Purpose of the Study:

  • To investigate script generation in patients with prefrontal and posterior cortical lesions compared to normal subjects.
  • To identify specific impairments in script information processing linked to lesion location.

Main Methods:

  • Comparative analysis of script generation tasks.
  • Assessment of action evocation, temporal sequencing, script closure, boundary adherence, and action importance estimation.
  • Inclusion of patients with prefrontal lesions (n=9), posterior lesions (n=8), and healthy controls (n=16).

Main Results:

Related Experiment Videos

  • Patients with prefrontal lesions exhibited significant impairments in script generation.
  • These impairments included errors in temporal sequencing, script closure, boundary adherence, and action importance estimation.
  • No significant differences were found between frontal, posterior, and normal subjects in action evocation, mean evocation time, or centrality.

Conclusions:

  • Prefrontal cortical lesions selectively impair script information processing.
  • These deficits are linked to difficulties in managerial knowledge, impacting planning and execution.
  • Findings highlight the prefrontal cortex's role in organized, goal-directed behavior.