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[Placental tissue histomorphometry in hydrops fetalis]
Placentae from 10 hydrops fetalis with hemoglobin Bart's disease were studied by tissue volumetry on the relative percentage of placental proper to its components, the surface area of villi and villi capillaries, and by comparing with 6 placentae from premature deliveries of 30-36 weeks. The placental weight, volume, percentage of placental proper and the villi volume, as well as the surface area of villi were significantly increased as compared with the controls. The relatively decreased volume percentage of intervillous space volume and surface area of villi capillaries resulted in a reduction of maternal-fetal exchanging surface area. We suggest careful prenatal scanning for Thalassemia and avoiding marriage between local peoples to reduce the incidence of hemoglobin Bart's disease.
Placentae from 10 hydrops fetalis with hemoglobin Bart's disease were studied by tissue volumetry on the relative percentage of placental proper to its components, the surface area of villi and villi capillaries, and by comparing with 6 placentae from premature deliveries of 30-36 weeks. The placental weight, volume, percentage of placental proper and the villi volume, as well as the surface area of villi were significantly increased as compared with the controls. The relatively decreased volume percentage of intervillous space volume and surface area of villi capillaries resulted in a reduction of maternal-fetal exchanging surface area. We suggest careful prenatal scanning for Thalassemia and avoiding marriage between local peoples to reduce the incidence of hemoglobin Bart's disease.