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Updated: Aug 18, 2026

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
Published on: April 29, 2011
Prothymosin alpha mRNA levels vary with c-myc expression during tissue proliferation, viral infection and heat shock
K Vareli1, M Frangou-Lazaridis, O Tsolas
1Laboratory of Biological Chemistry, University of Ioannina Medical School, Greece.
Abstract:
Expression of prothymosin alpha, an acidic nuclear protein implicated in cellular proliferation, has been reported to be regulated by c-myc in vitro. We have studied the correlation of expression levels between prothymosin alpha and c-myc, using three different in vivo systems, viz. normal ontogenic process of placental development, lytic viral infection and heat shock treatment. The two genes have been found to share a similar expression pattern, although prothymosin alpha mRNA remains always detectable, indicating the existence of yet another mechanism, in addition to c-myc, which regulates its expression in vivo.
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