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Migrating interstitial cells differentiate into neurons in hydra

C K Teragawa1, H R Bode

  • 1Department of Biological Science, Florida State University, Tallahassee 32306-3050, USA.

Developmental Biology
|October 1, 1995
PubMed
Summary

Interstitial cells migrate and differentiate into neurons in normal hydra, even without injury. This cell migration and neuron differentiation occurs in the head and peduncle, similar to grafted hydra.

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Hydra Research

Background:

  • Interstitial cell migration is known in grafted hydra.
  • The role of injury in stimulating cell migration was unclear.

Purpose of the Study:

  • To investigate interstitial cell migration and differentiation in normal, nongrafted hydra.
  • To determine if graft injuries are necessary to induce cell migration.

Main Methods:

  • Vital dye labeling of interstitial cells in intact hydra.
  • Observation of cell migration patterns and differentiation over 5 days.

Main Results:

  • Vital dye-labeled interstitial cells migrated throughout the body column.
  • Labeled neurons appeared among migrating cells, with numbers increasing over time.

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  • Cellular accumulation occurred primarily in the head and peduncle.

    • Conclusions:

    • Interstitial cell migration occurs in normal, non-grafted hydra.
    • Migration patterns in normal hydra mirror those observed in grafted hydra.
    • Migrating cells are likely neuron precursors.