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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
[Coronary angioplasty in chronic total occlusion: angiography results, complications, and predictive factors]
O Leonzi1, F Ettori, C Lettieri
1Divisione E Cattedra Di Cardiologia Spedali Civili e Università Di Brescia.
Insights
Coronary angioplasty for chronic total occlusions is successful in 77% of cases. Procedural success depends on occlusion duration and morphology, not patient factors.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Coronary angioplasty for chronic total occlusions (CTO) remains a complex interventional procedure with variable outcomes.
- Predictors of success and complications in CTO angioplasty require further investigation.
Purpose of the Study:
- To evaluate baseline clinical and angiographic predictors of success and complication rates in coronary angioplasty for CTO.
- To identify factors influencing procedural success in CTO interventions.
Main Methods:
- Retrospective analysis of 142 consecutive CTO angioplasty procedures performed between January 1989 and May 1993.
- Assessment of baseline clinical and angiographic parameters, procedural success, and complication rates.
Main Results:
- Procedural success was achieved in 77% of cases with a 2.8% major cardiac complication rate.
- Procedural success was significantly associated with the absence of bridging collaterals, occlusion duration under 3 months, and tapered or thrombotic occlusion morphology.
- Occlusion morphology was the most important determinant of success when bridging collaterals were absent.
Conclusions:
- Absence of bridging collaterals, shorter occlusion duration, and specific occlusion morphologies are key predictors of successful coronary angioplasty for CTO.
- Baseline clinical and angiographic factors were not predictive of complications or dissections, highlighting the importance of lesion characteristics for procedural success.
Abstract:
The results of coronary angioplasty of chronic total occlusions are still controversial. We examined baseline clinical and angiographic parameters and the success and complication rates of 142 consecutive procedures of coronary angioplasty of chronic occlusions selected among 1084 total procedures performed between January 1989 and May 1993. Procedural success was obtained in 109 procedures (77%) with 4 major cardiac complications (2.8%) consisting in one cardiac death caused by left main artery occlusion following an attempt of dilatation of an occluded left anterior descending artery, two non Q wave myocardial infarctions caused by distal embolization and one cardiac tamponade following artery perforation, successfully treated by pericardiocentesis. Extensive coronary dissection occurred in 24 procedures (17%): 5 caused vessel reocclusion and 19 were successfully treated by prolonged balloon inflation and/or use of long balloons or stent implantation. Among 15 baseline clinical and angiographic variables, none was predictive of cardiac complications or coronary artery dissection. In contrast, procedural success was significantly related with absence of bridging collaterals, duration of occlusion < 3 months and a tapered or thrombotic morphology of occlusion. Presence or absence of collaterals was the most significant variable selected by multivariate discriminant analysis. When patients with bridging collaterals were excluded from the analysis, occlusion morphology was the most important determinant. Success rates were 95% and 82% in patients with a tapered morphology lesion with < 3 months and > 3 months duration, respectively (ns); in contrast, success rates were 79% and 36% in patients with abrupt occlusion morphology of < and > 3 months duration (p = 0.001).
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