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[Long-term follow-up in polycythemia vera]
N Cohen-Goldenberg1, O Shpilberg, B Modan
1Institute of Hematology, Haim Sheba Medical Center, Tel Hashomer.
Harefuah
|June 1, 1995
Summary
This retrospective study analyzed 67 polycythemia vera patients treated between 1963-1990. Chemotherapy was common, with significant rates of hematological complications, thromboses, and bleeding observed.
Area of Science:
- Hematology
- Oncology
Context:
- Retrospective analysis of 67 patients diagnosed and treated for polycythemia vera between 1963 and 1990.
- Mean follow-up of 7.4 years, with a median actuarial overall survival of 23.6 years.
Purpose:
- To evaluate treatment modalities and outcomes in polycythemia vera patients over a defined period.
- To identify the incidence of hematological complications, thromboses, and bleeding in treated patients.
Summary:
- 50% of patients received a single chemotherapeutic agent, and 46% received combination chemotherapy.
- Phlebotomy was the sole treatment in only 4% of cases.
- Hematological complications occurred in 18%, thromboses in 18%, and bleeding in 21% of patients.
Impact:
- Provides long-term survival data for polycythemia vera patients treated with chemotherapy.
- Highlights the significant complication rates associated with historical treatment regimens.
- Informs understanding of the risks and benefits of different polycythemia vera treatment strategies.