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N-acetyltransferase activity--a susceptibility factor in human bladder carcinogenesis
A Dewan1, P Chattopadhyay, P K Kulkarni
1Department of Medical Toxicology, National Institute of Occupational Health, Meghani Nagar, Ahmedabad, Gujarat, India.
Indian Journal of Cancer
|March 1, 1995
Summary
Slow N-acetylator phenotype is linked to increased bladder cancer risk. This genetic trait, combined with smoking, significantly elevates the odds of developing bladder cancer, suggesting a susceptibility factor.
Area of Science:
- Pharmacogenomics
- Oncology
- Cancer Epidemiology
Background:
- Previous research indicates a higher prevalence of slow acetylator phenotypes in bladder cancer patients.
- Genetic variations in drug metabolism, such as acetylation, can influence cancer susceptibility.
Purpose of the Study:
- To investigate the association between slow N-acetylator phenotype and bladder cancer risk in a cohort of male patients.
- To evaluate the combined effect of slow N-acetylator phenotype and smoking on bladder cancer development.
Main Methods:
- Case-control study involving 77 male bladder cancer patients and 80 non-cancer controls.
- Phenotyping for slow acetylator status was performed on all participants.
- Statistical analysis, including odds ratio calculation, was used to assess risk factors.
Main Results:
- A significantly higher proportion of slow acetylator phenotypes was observed in bladder cancer patients (59.74%) compared to controls (35%) (p < 0.01).
- Smoking was also found to be a significant risk factor for bladder cancer (p < 0.01).
Conclusions:
- Slow N-acetylator phenotype is identified as a potential susceptibility factor for bladder cancer.
- The findings highlight the importance of genetic predisposition and environmental factors, like smoking, in bladder carcinogenesis.