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ADHD and thyroid abnormalities: a research note

T Spencer¹, J Biederman, T Wilens

¹Pediatric Psychopharmacology Unit (ACC-725), Massachusetts General Hospital, Boston 02114, USA.

Journal of Child Psychology and Psychiatry, and Allied Disciplines

|July 1, 1995

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This study found no evidence of generalized resistance to thyroid hormone in children with attention-deficit/hyperactivity disorder (ADHD). Mild thyroid function abnormalities were rare and not significantly different from the general population.

Area of Science:

Endocrinology
Neurodevelopmental Disorders
Pediatrics

Background:

Conflicting research exists regarding the link between attention-deficit/hyperactivity disorder (ADHD) and thyroid dysfunction.
The syndrome of generalized resistance to thyroid hormone (GRTH) has been specifically investigated in relation to ADHD.

Purpose of the Study:

To systematically review thyroid function in a large cohort of children and adolescents diagnosed with ADHD.
To investigate the prevalence of GRTH and other thyroid abnormalities in this population.

Main Methods:

A systematic review was conducted on a sample of 132 children and adolescents with ADHD.
Thyroid function tests were analyzed to assess for abnormalities.

Main Results:

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No evidence of generalized resistance to thyroid hormone (GRTH) was found in the ADHD group.
Mild thyroid function laboratory abnormalities were observed in a small percentage of subjects.
The rate of these mild abnormalities did not differ significantly from rates reported in healthy children.

Conclusions:

The study does not support an association between ADHD and generalized resistance to thyroid hormone.
While some mild thyroid function anomalies may occur in ADHD patients, they are not unique to this condition and do not appear to be clinically significant in most cases.