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A delayed hypersensitivity reaction to dentine primer in the guinea-pig
1Department of Operative Dentistry, School of Dentistry, Showa University, Japan.
Journal of Dentistry
|October 1, 1995
Abstract
Objective:
This study was undertaken to examine the possibility of a delayed hypersensitivity reaction or contact dermatitis occurring in the guinea-pig in response to methacrylate derivatives used as experimental dentine primers.
Methods:
The dentine primers 2-HEMA, GM, MA and MMA were tested in a guinea-pig maximization test.
Results:
All the dentine primers tested produced positive delayed hypersensitivity reactions in the guinea-pig. MMA produced the most severe reaction.
Conclusion:
It is concluded that in the clinical situation, clinicians and other members of the dental team should be aware of the need for careful handling of the dentine primers tested.