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Adenovirus cross-infection: a continuing problem

P E Klapper1, G M Cleator

  • 1North Manchester Virus Laboratory, Booth Hall Children's Hospital, UK.

The Journal of Hospital Infection
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

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Rapid adenovirus diagnosis using immune dot-blot assay (IDBT) significantly reduced outbreak duration in an eye hospital. This approach enables prompt control measures against adenovirus keratoconjunctivitis, improving patient outcomes.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Virology

Background:

  • Nosocomial adenovirus keratoconjunctivitis outbreaks pose significant challenges in healthcare settings.
  • Traditional viral isolation methods are time-consuming, delaying outbreak control measures.

Purpose of the Study:

  • To evaluate the effectiveness of a rapid diagnostic test, adenovirus immune dot-blot (IDBT), in managing nosocomial adenovirus outbreaks.
  • To compare the diagnostic speed and efficiency of IDBT with conventional cell culture methods.

Main Methods:

  • Retrospective analysis of two adenovirus keratoconjunctivitis outbreaks in a hospital's accident and emergency department.
  • Comparison of outbreak control strategies based on viral diagnosis methods: delayed cell culture isolation versus rapid IDBT.

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Main Results:

  • The first outbreak, diagnosed via cell culture, involved over 200 cases and was prolonged due to a two-month delay in control measures.
  • The second outbreak, utilizing IDBT, involved 23 cases and allowed for prompt identification and control.
  • IDBT offers a faster (5 days vs. 33 days) and more economical alternative to cell culture, though initial sensitivity was lower (67-84%).

Conclusions:

  • Rapid diagnostic tools like IDBT are crucial for timely intervention in adenovirus outbreaks.
  • Molecular diagnostic approaches are emerging as highly sensitive and rapid alternatives for adenovirus detection.