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Related Experiment Videos

Intravenous amitriptyline in pediatrics

J J Collins1, J Kerner, S Sentivany

  • 1Pain Treatment Service, Children's Hospital, Boston, Massachussetts 02115, USA.

Journal of Pain and Symptom Management
|August 1, 1995
PubMed
Summary

Intravenous (IV) amitriptyline offers a novel pain management option for children unable to take oral medications. This retrospective study explored its use in pediatric patients, noting one extrapyramidal reaction managed with diphenhydramine.

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Area of Science:

  • Pediatric pharmacology
  • Pain management
  • Neurology

Background:

  • Oral amitriptyline is a well-established analgesic.
  • Parenteral formulations exist but have limited clinical investigation beyond specific studies.
  • Intravenous (IV) administration offers an alternative for patients with oral intolerance.

Purpose of the Study:

  • To retrospectively review the use of IV amitriptyline in pediatric patients.
  • To assess indications, efficacy, and adverse events associated with IV amitriptyline in children.
  • To evaluate IV amitriptyline as an alternative analgesic and for other indications in pediatric patients.

Main Methods:

  • Retrospective chart review of eight pediatric patients (aged 5-16.6 years) who received IV amitriptyline.

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  • Indications included neuropathic pain, depression, sleep disturbance, and opioid adjuvant therapy.
  • Adverse events and management strategies were documented.

    • Main Results:

    • IV amitriptyline was administered to children unable to tolerate oral medications.
    • The drug was used for various indications including pain, depression, and sleep disturbances.
    • One patient experienced an extrapyramidal reaction, successfully treated with diphenhydramine.

    Conclusions:

    • IV amitriptyline may be a viable option for pediatric patients with medication intolerance.
    • Further prospective, controlled studies are necessary to confirm safety, efficacy, and tolerability.
    • This route of administration warrants further investigation for diverse pediatric conditions.