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Hemorrheologic effects of metabolites of pentoxifylline (Trental)
J L Ambrus1, S Stadler, M Kulaylat
1Department of Internal Medicine, State University of New York at Buffalo, USA.
Journal of Medicine
|January 1, 1995
Abstract:
Pentoxifylline (Trental) is metabolized by red blood cells and the liver into seven metabolites. Metabolites I and V have significant hemorrheologic effects. They are both similar to pentoxifylline in their activity on red blood cell membrane fluidity. Metabolite I is more active than pentoxifylline in inhibiting ADP-induced platelet aggregation. Metabolite V is more active than pentoxifylline in inhibiting epinephrine-induced platelet aggregation.