Related Experiment Videos
Schwannoma-derived growth factor interacts with the epidermal growth factor receptor
1Department of Molecular and Cellular Growth Biology, Whittier Institute for Diabetes and Endocrinology; La Jolla, California, USA.
Journal of Neurochemistry
|October 1, 1995
Abstract:
Schwannoma-derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF receptor but not HER2/neu.