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Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica
S Ohnishi1, N Fukamiya, M Okano
1Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan.
Journal of Natural Products
|July 1, 1995
Abstract:
Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI50 values in the range of -4.14 to -5.72.