[Cytotoxicity of aspidospermane indole alkaloids with a modified tryptamine chain]

Eight synthetic indole alkaloids with the aspidospermane structure have ben evaluated for cytotoxicity in the L-1210 cell culture test system. Two of them (compounds 9 and 5), bearing a modified tryptamine chain, were significantly active (IC50 values of 0.7 and 3.1 microM, respectively).