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Human parvovirus B19 in pregnancy
1Johns Hopkins Hospital, Baltimore, MD, USA.
Summary
Human parvovirus infection poses a significant risk to seronegative childbearing women. While maternal illness is mild, the fetus can develop hydrops fetalis and die, necessitating provider awareness.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Fetal Medicine
Background:
- Human parvovirus infection is a serious concern for pregnant individuals.
- Seronegative women are particularly vulnerable to severe fetal outcomes.
- The infection can lead to nonimmune hydrops fetalis and fetal demise.
Purpose of the Study:
- To highlight the risks of human parvovirus in pregnancy.
- To inform healthcare providers about parvovirus transmission and management.
- To emphasize the importance of recognizing this often-unrecognized infection.
Main Methods:
- Review of existing literature on human parvovirus in pregnancy.
- Analysis of disease presentation, transmission, and fetal sequelae.
- Discussion of clinical management strategies.
Main Results:
- Maternal symptoms are typically mild.
- Fetal exposure can rapidly lead to nonimmune hydrops fetalis.
- Untreated fetal parvovirus infection has a high mortality rate.
Conclusions:
- Healthcare providers must be aware of human parvovirus risks in seronegative pregnant women.
- Prompt recognition and management are crucial for improving fetal outcomes.
- Understanding parvovirus transmission is key to prevention and care.