Related Experiment Video
Updated: Aug 8, 2026

07:49
Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Exercise-induced anaphylaxis related to specific foods
S Tilles1, A Schocket, H Milgrom
1Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine.
The Journal of Pediatrics
|October 1, 1995
Summary
A 16-year-old experienced exercise-induced anaphylaxis after eating pizza and cheese. Identifying specific trigger foods is crucial for managing this severe allergic reaction.
Area of Science:
- Allergy and Immunology
- Clinical Case Study
- Food Hypersensitivity
Background:
- Exercise-induced anaphylaxis (EIA) is a rare condition requiring careful diagnosis.
- Identifying specific food triggers is essential for effective management of EIA.
- This case highlights the link between common foods and exercise-induced allergic reactions.
Observation:
- A 16-year-old female presented with symptoms of anaphylaxis during physical activity.
- Challenge testing confirmed that consuming pizza and a cheese sandwich precipitated the anaphylactic episodes.
- The patient's history revealed a temporal association between food intake and exercise.
Findings:
- Specific food triggers, such as pizza and cheese, can precipitate exercise-induced anaphylaxis.
- Delayed food avoidance (12 hours) may be necessary if a specific coprecipitating food is identified.
- General recommendations include avoiding food 6-8 hours before exercise and immediate cessation of activity upon symptom onset.
Implications:
- Patients with EIA should be educated on trigger avoidance and emergency preparedness.
- Prompt administration of epinephrine by a companion is critical in managing EIA episodes.
- Further research into the mechanisms of food-dependent EIA is warranted.
Related Concept Videos
Cross-reactivity
Overview
Allergic Reactions
Overview
Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

