Poisoning with anti-hypertensive drugs: alpha-adrenoceptor antagonists

Experience with overdosage and toxicity with the alpha (alpha)-adrenoceptor antagonists remains very limited, and all the cases in the literature relate to prazosin overdosage. The selective alpha-blocker appears, however, to have a low acute toxicity. Supportive therapy by the reduction of gastrointestinal absorption, monitoring of vital signs and the correction of hypotension (with intravenous fluids) is indicated.