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Takayasu's arteritis in Kuwait
K el-Reshaid1, J Varro, Q al-Duwairi
1Department of Medicine, Faculty of Medicine, Kuwait University.
The Journal of Tropical Medicine and Hygiene
|October 1, 1995
Summary
Takayasu
Area of Science:
- Vascular Medicine
- Rheumatology
- Epidemiology
Background:
- Takayasu's arteritis (TA) is a rare, chronic inflammatory disease affecting large arteries.
- Understanding its epidemiology and clinical presentation in diverse populations is crucial for diagnosis and management.
Purpose of the Study:
- To describe the epidemiological profile and clinical features of Takayasu's arteritis in Kuwait.
- To investigate associations with autoimmune diseases and hypercoagulable states.
Main Methods:
- Retrospective analysis of 13 patients diagnosed with Takayasu's arteritis between 1989 and 1994.
- Diagnosis confirmed by angiographic studies.
- Coagulation tests, including antiphospholipid antibody (aPL) assays, were performed in a subset of patients.
Main Results:
- Takayasu's arteritis is not rare in the Arabic population, with a notable presentation of renal disease secondary to abdominal aorta involvement (TA, type II).
- Female predominance was not observed in this cohort.
- Only one patient had recurrent thrombosis linked to antiphospholipid antibodies and protein S deficiency, with positive serology for systemic lupus erythematosus (SLE).
Conclusions:
- Takayasu's arteritis presents distinct features in the Arabic population, including a higher prevalence of type II disease.
- The association with SLE and primary hypercoagulable states was inconsistent, questioning the universal role of thrombotic vasculopathy in TA pathogenesis.
- Further research is needed to elucidate the specific etiological factors and clinical variations of Takayasu's arteritis across different ethnic groups.