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Nucleolar organizer regions: a new prognostic factor for upper tract urothelial cancer
1Department of Urology, Yokohama City University School of Medicine, Kanagawa-ken, Japan.
Purpose:
The prognostic significance of argyrophilic staining in the nucleolar organizer regions was studied in 63 patients with primary urothelial tumors of the renal pelvis and ureter.
Materials And Methods:
Silver staining of paraffin embedded sections was performed using a 1-step technique.
Results:
The prognosis for patients with a mean number of argyrophilic nucleolar organizer region proteins per nucleus (argyrophilic nucleolar organizer region score) of 8 or greater was significantly worse than that for patients with a score of less than 8 (P <0.001).
Conclusions:
Argyrophilic nucleolar organizer region score is a new prognostic factor in primary urothelial tumors of the renal pelvis and ureter, and it is particularly useful for patients with invasive tumors.