[The structure and function of the renal interstitial cells]

The researchers analyzed the composition of renal interstitial cells using histological and immunohistochemical techniques. They examined the distribution of fibroblast-like cells in the cortex and medulla. The study involved assessing the expression of HLA-class 2, ICAM-1, and VCAM-1. They observed the proliferation of interstitial cells around damaged tubules. The team also investigated the secretion of procollagen and PGE2. The study compared healthy and diseased kidney tissues. They evaluated interactions between interstitial cells and blood components. The methods included both in vitro and in vivo observations.

The fibroblast-like cells formed a reticular network between tubules and capillaries. In disease states, these cells expressed HLA-class 2 and adhesion molecules. The expression levels correlated with leukocyte infiltration and tubulitis. Around injured tubules, interstitial cells proliferated and formed lymphatic-like structures. In fibrosis, both interstitial and epithelial cells secreted procollagen. The interstitial cells also played a role in resolving fibrotic deposits. Medullary cells responded to angiotensin 2 and bradykinin by secreting PGE2. The interactions between interstitial cells and tubular epithelial cells were confirmed.

The study suggests that renal interstitial cells are involved in both structural and inflammatory responses. The authors propose that these cells contribute to lymphatic formation during injury. They note that interstitial cells may resolve fibrosis by secreting procollagen. The findings indicate a complex interaction between interstitial cells and other renal cells. The study highlights the role of adhesion molecules in leukocyte infiltration. The authors suggest that interstitial cells respond to angiotensin 2 and bradykinin. They emphasize the need for further research into the mechanisms of fibrosis. The study does not assign essentiality to any specific function of these cells.