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Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

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[Tumorigenesis of kidney tubule]

I Ishikawa1

  • 1Department of Internal Medicine, Kanazawa Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1995
PubMed

Insights

Renal cell carcinoma (RCC) originates from kidney structures. Clear cell RCC involves chromosomal changes, while papillary RCC progresses through stages and shows numeric chromosomal alterations.

Area of Science:

  • Nephrology
  • Oncology
  • Genetics

Context:

  • Renal cell carcinoma (RCC) arises from renal tubules, blastematous tubules, or nephrogenic rests.
  • Clear cell RCC, the most common type, is associated with structural chromosomal changes, particularly involving tumor suppressor genes like VHL at 3p14, 3p21, or 3p25.
  • Papillary RCC, in contrast, progresses sequentially from atypical tubules to adenoma and then carcinoma, characterized by numeric chromosomal changes.

Purpose:

  • To differentiate the cytogenetic origins and progression pathways of clear cell and papillary renal cell carcinoma.
  • To highlight the chromosomal abnormalities associated with different RCC subtypes.
  • To note the association of papillary RCC with acquired renal cysts in dialysis patients.

Summary:

  • Clear cell renal cell carcinoma (RCC) exhibits structural chromosomal changes, often affecting tumor suppressor genes (e.g., VHL).
  • Papillary RCC shows a sequential progression from atypical tubules to carcinoma, with numeric chromosomal alterations.
  • Dialysis-associated acquired renal cysts in RCC patients are linked to the papillary subtype.

Impact:

  • Provides a clearer understanding of the distinct genetic mechanisms underlying clear cell and papillary RCC.
  • Suggests potential differences in tumorigenesis and progression based on cytogenetic profiles.
  • Informs future research into the specific genetic drivers and potential therapeutic targets for different RCC subtypes.

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