Related Experiment Video
Updated: Aug 6, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Tubulointerstitial nephropathy secondary to collagen-vascular diseases]
1Nephrology Center, Toranomon Hospital.
Abstract:
Although collagen-vascular diseases mainly affect glomeruli and vessels, tubulointerstitial (TI) involvements as well, are frequently demonstrated histologically. In renal biopsy specimens from patients with lupus erythematosus, tubular atrophy, mononuclear (MN) cell infiltration into the interstitium and interstitial fibrosis are demonstrated in nearly 50% of cases. Immunoglobulins and complement components are sometimes deposited along tubular basement membrane, suggesting an immune-complex mediated mechanism. Infiltrating cells are mainly T cells, but the surface marker studies are not conclusive as to the subset of T cells responsible for the inflammation. As for Sjögren syndrome, TI changes and renal tubular acidosis are the prominent features of the disease. MN cell infiltration in the renal interstitium is also reported in patients with systemic vasculitis.
Related Concept Videos
Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can exist in...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Nephrotic Syndrome I : Introduction
Acute Kidney Injury II: Pathophysiology
Healing II: Complications

