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Related Experiment Videos

Inferior rectal nerve stimulation for anal sphincteric control: experimental study

A Shafik1

  • 1Department of Surgery and Research, Faculty of Medicine, Cairo University, Egypt.

The Journal of Surgical Research
|October 1, 1995
PubMed
Summary

Inferior rectal nerve (IRN) stimulation effectively enhances external anal sphincter (EAS) activity and rectal neck pressure. Optimal results were observed at 50 Hz, suggesting potential for restoring EAS tone through chronic electrostimulation.

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Bioengineering

Background:

  • Sphincteric control of the rectal neck is crucial for fecal continence.
  • Understanding the neural pathways involved in rectal function is essential for developing therapeutic strategies.
  • The inferior rectal nerve (IRN) plays a role in innervating the external anal sphincter (EAS).

Purpose of the Study:

  • To investigate the effects of inferior rectal nerve (IRN) stimulation on rectal neck pressure and external anal sphincter (EAS) electromyographic (EMG) activity.
  • To determine the optimal stimulation parameters for evoking a response in the EAS and rectal neck.
  • To assess the feasibility of chronic electrostimulation for restoring EAS function.

Main Methods:

  • Eight dogs were utilized under anesthesia for the study.

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  • The inferior rectal nerve (IRN) was surgically exposed via a para-anal incision.
  • Bipolar electrodes were applied to the IRN to deliver electrical stimulation.
  • Rectal pressure, rectal neck pressure, and EAS EMG activity were measured in response to IRN stimulation at varying frequencies.
  • Nerve responsiveness, electrode migration, and electrode integrity were monitored during long-term activation.

    • Main Results:

    • IRN stimulation significantly increased rectal neck pressure (P < 0.01) and EAS EMG activity (P < 0.01).
    • The response magnitude increased with stimulation frequency up to 50 Hz, with no further increase beyond this point.
    • Rectal pressure remained unchanged (P > 0.05).
    • Increased stimulation led to decreased latency and duration of the response.
    • Response recovery was observed after an off-time twice the stimulation phase duration.
    • Long-term activation did not impair nerve responsiveness or cause electrode-related issues.

    Conclusions:

    • A stimulation frequency of 50 Hz elicits the most effective EAS contraction and rectal neck pressure elevation.
    • Chronic electrostimulation of the perineal nerve, potentially including the IRN, shows promise for restoring EAS tone.
    • These findings support the potential of neuromodulation for managing conditions affecting fecal continence.