Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Castleman's disease

H Shahidi1, J L Myers, P A Kvale

  • 1Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.

Mayo Clinic Proceedings
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Castleman's disease presents in localized and multicentric forms. Multicentric Castleman's disease requires aggressive treatment and has a poor prognosis, unlike the localized type.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frozen sections in patients undergoing breast conserving surgery at a single ambulatory surgical center: 5 year experience.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2017
Same author

Benefits of pulsatile flow in pediatric cardiopulmonary bypass procedures: from conception to conduction.

Perfusion·2011
Same author

Hemodynamic evaluation of arterial and venous cannulae performance in a simulated neonatal extracorporeal life support circuit.

Perfusion·2011
Same author

The role of semantic knowledge in retrieval from episodic long-term memories: Implications for a model of retrieval.

Memory & cognition·2011
Same author

Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema.

The European respiratory journal·2010
Same author

Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2009

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Castleman's disease is a rare lymphoproliferative disorder.
  • It is characterized by lymphadenopathy and systemic symptoms.
  • Two main variants exist: hyaline-vascular and plasma-cell types.

Observation:

  • The hyaline-vascular type is typically localized and treated with surgical excision.
  • The multicentric variant presents with severe systemic manifestations and a poor prognosis.
  • Histologic features are crucial for differentiating the types.

Findings:

  • Multicentric Castleman's disease often necessitates aggressive systemic therapy.
  • Faulty immunoregulation leading to B lymphocyte and plasma cell proliferation is implicated.
  • The exact cause remains poorly understood.

Related Experiment Videos

Implications:

  • Accurate diagnosis requires excluding other causes of lymphadenopathy.
  • Optimal therapeutic regimens for multicentric Castleman's disease are still under investigation.
  • Further research into the pathogenesis is needed for improved treatment strategies.