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Establishing a multivariate clinical laboratory data base

R R Grams, D Lezotte, J C Gudat

    Journal of Medical Systems
    |January 1, 1978
    PubMed
    Summary
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    This study details a clinical laboratory program for establishing reference values using healthy subjects. It provides essential univariate and multivariate data for laboratory interpretation and quality control.

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Biostatistics

    Background:

    • Establishing accurate reference values is crucial for clinical laboratory diagnostics.
    • Hospital-based reference value studies are feasible for clinical laboratories.
    • Existing methods require robust validation and quality control.

    Purpose of the Study:

    • To describe a practical program for generating regional or hospital-based reference values.
    • To provide data for both univariate and multivariate interpretations.
    • To validate and ensure quality control for clinical laboratory methods.

    Main Methods:

    • Sampling one to two healthy subjects daily under controlled conditions.
    • Simultaneously testing sixty-seven biochemical and hematological variables.

    Related Experiment Videos

  • Calculating univariate age and sex ranges, variance/covariance matrices, and correlation coefficients.

    • Main Results:

    • The program generates comprehensive univariate and multivariate data.
    • Age and sex-specific reference ranges are established.
    • Variance and covariance data provide insights into variable interrelationships.

    Conclusions:

    • This ongoing reference value program is essential for clinical laboratories.
    • It supports accurate diagnostic interpretations and method validation.
    • The program enhances overall laboratory quality assurance.