Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spontaneous periodic hypothermia

R T Kloos1

  • 1Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.

Medicine
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No calcitonin change in a person taking dulaglutide diagnosed with pre-existing medullary thyroid cancer.

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

Follow-up of low-risk differentiated thyroid cancer patients who underwent radioiodine ablation of postsurgical thyroid remnants after either recombinant human thyrotropin or thyroid hormone withdrawal.

The Journal of clinical endocrinology and metabolism·2009
Same author

Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study.

The Journal of clinical endocrinology and metabolism·2005
Same author

Hashimoto's thyroiditis with papillary thyroid carcinoma (PTC)-like nuclear alterations express molecular markers of PTC.

Histopathology·2004
Same author

Nasolacrimal obstruction secondary to I(131) therapy.

Ophthalmic plastic and reconstructive surgery·2004
Same author

Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy.

Gene therapy·2004

Spontaneous periodic hypothermia is a rare condition causing recurrent, central hypothermia without a clear cause. While not fatal, it presents serious systemic effects, and its underlying mechanisms require further investigation.

Area of Science:

  • Neurology
  • Thermoregulation
  • Rare Diseases

Background:

  • Spontaneous periodic hypothermia (SPH) is a rare syndrome characterized by recurrent episodes of central hypothermia.
  • It occurs without identifiable systemic causes or brain lesions, with patients defending a lowered temperature set point.

Observation:

  • Patients exhibit systemic consequences of hypothermia despite defending a temporary lower temperature.
  • No deaths are directly attributed to SPH, but serious systemic effects are documented.

Findings:

  • The exact cause of SPH and Shapiro syndrome remains unknown.
  • Pharmacologic trials, including anticonvulsants, clonidine, and cyproheptadine, show modest success, with cyproheptadine as a potential first choice.
  • Potential mechanisms involve structural abnormalities, trauma, infection, or degeneration affecting thermoregulatory centers, possibly linked to diencephalic epilepsy.

Related Experiment Videos

Implications:

  • Further research is needed to understand the pathophysiology of SPH.
  • Advanced neuroimaging techniques like PET and SPECT scans during episodes could provide valuable insights.
  • A more pathophysiologically meaningful nomenclature is expected as understanding of SPH improves.