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Parathyroid hormone-related peptide expression in endocrine tumors
S Nagataki1, M Nakashima, K Akino
1First Department of Internal Medicine, Nagasaki University School of Medicne, Japan.
Mineral and Electrolyte Metabolism
|January 1, 1995
Abstract:
Parathyroid hormone-related peptide (PTHrP) expression is associated with the histological type in pituitary tumor, but not in thyroid carcinoma. However invasive and metastatic tumors showed intense PTHrP staining in both pituitary and thyroid tumors. Analysis of the established metastatic rat pituitary tumor cell line showed that PTHrP plays a crucial role in in vivo cell proliferation closely related to worsening of malignant transformation and neovascularization in a paracrine fashion.