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Effect of calcium supplementation on bone density and parathyroid function in elderly subjects
Mineral and Electrolyte Metabolism
|January 1, 1995
Summary
Heated oyster shell-seaweed calcium (HOSS Ca) improved bone mineral density in elderly women more effectively than calcium carbonate. This new calcium preparation shows promise for treating age-related bone loss.
Area of Science:
- Gerontology
- Nutritional Science
- Biochemistry
Background:
- Secondary hyperparathyroidism in the elderly is influenced by calcium absorption.
- Bioavailability of calcium supplements varies, impacting clinical effectiveness.
Purpose of the Study:
- To evaluate the bioavailability and clinical utility of a novel calcium preparation, heated oyster shell-seaweed calcium (HOSS Ca).
- To compare HOSS Ca against calcium carbonate and placebo in elderly women.
Main Methods:
- Randomized, prospective, double-blind trial involving 58 hospitalized women (mean age 82).
- Groups received 900 mg/day of HOSS Ca, calcium carbonate (CaCO3), or placebo for 18 months.
- Bone mineral density (BMD) at the lumbar spine and midradius, whole body calcium content, and urinary calcium/creatinine ratios were measured.
Main Results:
- Lumbar spine BMD increased significantly more with HOSS Ca compared to placebo.
- HOSS Ca group showed a significantly smaller decrease in whole body calcium content over time compared to placebo.
- Urinary calcium/creatinine ratios indicated different absorption patterns among the groups.
Conclusions:
- Heated oyster shell-seaweed calcium (HOSS Ca) demonstrates superior efficacy in preserving bone mineral density in elderly women compared to calcium carbonate.
- HOSS Ca represents a potentially more effective calcium supplement for addressing age-related bone health issues.