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Genotoxicity of the herbicide butachlor in cultured human lymphocytes
S Sinha1, N Panneerselvam, G Shanmugam
1Cancer Biology Division, School of Biological Sciences, Madurai Kamaraj University, India.
Mutation Research
|August 1, 1995
Abstract:
Butachlor, a pre-emergence herbicide was investigated for its ability to induce sister chromatid exchanges (SCE) and chromosome aberrations (CA) in cultured human peripheral blood lymphocytes. Mitogen-stimulated lymphocytes were treated with three different concentrations (5, 10 and 20 micrograms/ml) of butachlor for 24, 48 and 72 h. Our results indicate a dose-dependent increase in the frequency of chromosomal aberrations at 24, 48 and 72 h of treatment with butachlor. No SCE was promoted by butachlor.