Related Experiment Videos
Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes
S Simi1, S Morelli, P G Gervasi
1Genetica e Biochimica Tossicologica, Istituto di Mutagenesi e Differenziamento CNR, Pisa, Italy.
Mutation Research
|August 1, 1995
Abstract:
The clastogenicity of seven anthraquinones was investigated in a V79 Chinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The results have shown that chromosomal aberrations are modulated in similar manner both in parental and transfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.