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RET/PTC oncogene activation is an early event in thyroid carcinogenesis
G Viglietto1, G Chiappetta, F J Martinez-Tello
1Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Italy.
Oncogene
|September 21, 1995
Abstract:
RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.