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Related Experiment Videos

Immune responses during an Antarctic summer

H K Muller1, D J Lugg, H Ursin

  • 1Department of Pathology, University of Tasmania, Hobart, Australia.

Pathology
|April 1, 1995
PubMed
Summary

Antarctic expeditions can suppress immune responses, particularly cell-mediated immunity (CMI), correlating with anxiety. This immune alteration may impact health in extreme environments.

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Area of Science:

  • Immunology
  • Psychoneuroimmunology
  • Environmental Medicine

Background:

  • The immune system's response to extreme environments is not fully understood.
  • Isolated and extreme conditions, such as Antarctic expeditions, present unique stressors.
  • Understanding immune function during such missions is crucial for crew health.

Purpose of the Study:

  • To investigate immune status changes in expedition members during an Antarctic voyage.
  • To correlate immune responses with psychological and physiological parameters.
  • To explore implications for health management in isolated environments.

Main Methods:

  • Assessed cell-mediated immune responses (CMI) using the CMI Multi-test in 29 healthy expedition members.
  • Monitored T and B lymphocyte subsets, immunoglobulin, complement, and cortisol levels.

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  • Correlated immune data with psychological parameters like anxiety before, during, and after the voyage.

    • Main Results:

    • A significant decrease in cell-mediated immune responses (CMI) was observed, with 21% showing hypoergy.
    • Reduced CMI correlated negatively with anxiety experienced in Antarctica.
    • No significant changes were noted in lymphocyte subsets, immunoglobulins, complement, or blood flow; cortisol was low pre-departure.

    Conclusions:

    • Antarctic deployment can depress immune function, particularly CMI, potentially linked to stress and anxiety.
    • Alterations in immune control mechanisms, like reduced CMI and antibody levels, were evident.
    • Findings highlight the need for health management strategies addressing immune changes in isolated, extreme conditions.