Clear cell carcinoma simulating the "endometrioid-like variant" of yolk sac tumor

The authors report a case of clear cell carcinoma of the ovary simulating the "endometrioid-like variant" of YST only recently described by Clement. The tumor was characterized histologically by a villoglandular component intermingled with an endometrioid like glandular pattern, nuclear pleomorphism with abnormal mitotic figures, eosinophilic hyaline PAS-D resistant bodies and diffuse, typical sopranuclear and subnuclear vacuolization according to Clement's description. Clinical features as the old age of the patient and laboratory investigations, suggested the possibility of a surface epithelial origin of the neoplasia, that was substantiated by subsequent additional sections and by immunohistochemical staining for AFP, AAT and CEA.