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Validation of electronic cell counts by quantitative buffy coat analysis (QBC)
1Laboratoire d'Hematologie, Centre Hospitalier Universitaire de Grenoble, France.
Nouvelle Revue Francaise D'Hematologie
|January 1, 1995
Summary
The QBC system accurately flags electronic cell counter results, reducing manual validation and infection risks. It also helps identify potential hemoglobinopathies by detecting microcytosis and hypochromia.
Area of Science:
- Hematology
- Clinical Pathology
Background:
- Electronic cell counters are standard for blood cell counts.
- Manual validation of electronic counter flags carries risks of infection and contamination.
- The QBC system offers an alternative method for blood analysis.
Purpose of the Study:
- To evaluate the accuracy and utility of the QBC system compared to electronic cell counters.
- To assess the QBC system's role in quality control and identifying potential hematological disorders.
Main Methods:
- Performed 458 blood cell counts using both an electronic cell counter and the QBC system.
- Conducted parallel blood film reviews for comparative analysis.
Main Results:
- The QBC system provided fast and accurate control of electronic counter flags in most cases.
- Manual validation was often unnecessary, mitigating infection and contamination risks.
- QBC non-readability correlated with microcytosis and hypochromia, suggesting hemoglobinopathies.
Conclusions:
- The QBC system is a valuable tool for quality control in blood cell counting.
- It enhances efficiency and safety by reducing manual validation needs.
- QBC analysis can aid in the preliminary identification of hemoglobinopathies.