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[The effects of growth hormone in children with a GH deficiency: a report of 5 cases]
G Chessa Ricotti1, R Cutrì, A De Bernardi
1U.O. di Pediatria, Nuovo Ospedale San Giovanni di Dio di Firenze, Italia.
Insights
Idiopathic growth hormone deficiency (GHD) in children responded well to human growth hormone therapy. Recombinant human growth hormone (rhGH) proved safe and effective in most prepubertal cases studied.
Area of Science:
- Pediatric Endocrinology
- Growth Hormone Therapy
- Child Health
Background:
- Idiopathic growth hormone deficiency (GHD) affects children's growth.
- Prepubertal children with GHD require effective treatment.
- Human growth hormone (hGH) is a standard therapy for GHD.
Purpose of the Study:
- To evaluate the efficacy and safety of human growth hormone (hGH) treatment.
- To assess the response to rhGH in prepubertal children with idiopathic GHD.
Main Methods:
- Case series of 5 prepubertal children (3 boys, 2 girls) with idiopathic GHD.
- Treatment administered using human growth hormone (hGH).
- Response to therapy monitored in all cases.
Main Results:
- Four out of five children showed a significant response to rhGH treatment.
- One case (F1) exhibited a negative response to the therapy.
- The overall treatment demonstrated positive outcomes in the majority of patients.
Conclusions:
- Recombinant human growth hormone (rhGH) is a safe therapeutic option.
- rhGH is an effective treatment for children diagnosed with GHD.
- Treatment outcomes suggest rhGH is beneficial for prepubertal GHD.
Abstract:
The authors describe 5 cases, 3 boys and 2 girls, with idiopathic growth hormone deficiency in prepubertal age, treated with human growth hormone. In four of five cases the response to treatment with GH was relevant. Only in one case (F1) the response was negative. The results of this study confirm that rhGH is a safe and effective therapy in children with GHD.