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Related Experiment Videos

Post-typhoid anhidrosis: a clinical curiosity

V Raveenthiran1

  • 1Department of Medicine, Stanley Medical College, Madras, India.

Postgraduate Medical Journal
|July 1, 1995
PubMed
Summary

A 19-year-old experienced generalized anhidrosis (inability to sweat) after typhoid fever. Investigations found damaged eccrine glands, suggesting typhoid may affect sweat pathways.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Physiology

Background:

  • Anhidrosis, or the inability to sweat, can result from various conditions affecting thermoregulation.
  • Typhoid fever is a bacterial infection that can lead to a range of systemic complications.

Observation:

  • A 19-year-old female presented with generalized anhidrosis post-typhoid fever.
  • Extensive medical investigations revealed no other significant abnormalities.
  • Skin biopsy showed both atrophic (damaged) and normal eccrine glands.

Findings:

  • The case represents the third documented instance of post-typhoid anhidrosis in English literature.
  • Histopathological examination of the skin revealed eccrine gland atrophy.

Implications:

  • This case suggests a potential link between typhoid fever and damage to the efferent sweating pathway.
  • Further research is warranted to understand the mechanisms of thermoregulatory dysfunction following typhoid fever.

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