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Related Experiment Videos

[Lymphomatoid papulosis]

B Dreno1

  • 1Clinique dermatologique, Hôtel-Dieu, Nantes.

Presse Medicale (Paris, France : 1983)
|June 24, 1995
PubMed
Summary
This summary is machine-generated.

Lymphomatoid papulosis presents as recurring skin lesions with malignant cells, often T helper phenotype expressing Ki-1 (CD30). Its classification as benign or lymphoma is debated, with evidence suggesting a spectrum with CD30 lymphomas.

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Area of Science:

  • Dermatopathology
  • Oncology
  • Immunology

Context:

  • Lymphomatoid papulosis (LyP) is characterized by recurrent crops of hemorrhagic and necrotic papules.
  • The infiltrate consists of atypical T cells, often with an active T helper phenotype.
  • Expression of Ki-1 (CD30) antigen is a hallmark of LyP.

Purpose:

  • To explore the nature of the aberrant cells in LyP.
  • To investigate the relationship between LyP and other CD30-positive lymphoid disorders.
  • To discuss the controversial classification of LyP as benign or malignant.

Summary:

  • LyP exhibits a cytologically malignant infiltrate, with aberrant cells typically being T helper phenotype.
  • The presence of Ki-1 (CD30) on infiltrating cells links LyP to Hodgkin's disease and T-cell lymphomas.

Related Experiment Videos

  • Clonality studies using T cell receptor gene rearrangement suggest a monoclonal population, raising concerns about malignant transformation.
  • Recent views propose LyP and Ki-1 (CD30) lymphomas exist on a spectrum of cutaneous lymphoid infiltrates.

    • Impact:

    • Clarifies the diagnostic criteria and potential malignant behavior of LyP.
    • Highlights the association between LyP and other CD30-expressing lymphomas.
    • Contributes to the ongoing debate regarding the classification of LyP.
    • Suggests a unified spectrum for cutaneous CD30-positive lymphoid infiltrates.