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[Study of oxidative stress in the elderly]
F Congy1, D Bonnefont-Rousselot, S Dever
1Centre de Moyen et Long Séjour, Hôpital de la Salpêtrière, Paris.
Presse Medicale (Paris, France : 1983)
|July 1, 1995
Summary
Elderly individuals exhibit increased oxidative stress markers, indicating a potential biological marker of aging. Antioxidant supplementation, particularly with selenium, may be beneficial for this population.
Area of Science:
- Gerontology
- Biochemistry
- Oxidative Stress Research
Background:
- Aging is associated with increased oxidative stress.
- Understanding oxidative stress markers in the elderly is crucial for health management.
Purpose of the Study:
- To determine the oxidative stress status in elderly subjects.
- To evaluate the significance of oxidative stress as a biological marker of aging.
Main Methods:
- Compared six oxidative stress parameters in 52 elderly patients and 30 young controls.
- Assessed plasma thiobarbituric acid reactive substances, vitamin E, selenium, and erythrocyte superoxide dismutase and glutathione peroxidase activity.
Main Results:
- Elderly subjects showed higher thiobarbituric acid reactive substances and lower superoxide dismutase, glutathione peroxidase, and selenium levels compared to young controls.
- Vitamin E levels did not differ between groups.
- Specific correlations between oxidative stress markers were observed in nursing home residents.
Conclusions:
- Oxidative stress is evident in the elderly and may serve as a biological marker of aging.
- Supplementation with selenium or other antioxidants could be a potential therapeutic strategy.