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[Intoxication indicators in the diagnosis of tuberculosis activity in children]
Insights
Assessing intrathoracic lymph node tuberculosis activity in children can be done by measuring low- and middle-mass substances in blood. Active tuberculosis showed higher levels, with treatment reducing intoxication but not to normal levels.
Area of Science:
- Pediatrics
- Infectious Diseases
- Biochemistry
Background:
- Intrathoracic lymph node tuberculosis is a significant concern in pediatric populations.
- Assessing the activity and intoxication levels in pediatric tuberculosis is crucial for effective management.
- Current diagnostic methods may not fully capture the extent of systemic effects.
Purpose of the Study:
- To evaluate the utility of blood plasma and red cell low- and middle-mass substances as indicators of intrathoracic lymph node tuberculosis activity in children.
- To assess the impact of etiopathogenetic treatment on intoxication levels in these patients.
Main Methods:
- Analysis of blood plasma and red cell levels of low- and middle-mass substances in 44 children.
- Categorization of children into three groups: M.tuberculosis infected, active intrathoracic lymph node tuberculosis, and treated for the disease.
- Comparison of substance levels between groups and assessment of changes after treatment.
Main Results:
- Children with active intrathoracic lymph node tuberculosis exhibited significantly higher levels of low- and middle-mass substances compared to controls.
- Etiopathogenetic treatment for a minimum of 4 months resulted in a reduction of intoxication markers.
- Despite treatment, intoxication levels did not fully return to control concentrations.
Conclusions:
- Blood levels of low- and middle-mass substances can serve as indicators for judging the activity of intrathoracic lymph node tuberculosis in children.
- While treatment alleviates intoxication, persistent sub-optimal levels suggest the need for further therapeutic strategies or longer treatment durations.
Abstract:
It is suggested to judge on the activity of intrathoracic lymph node tuberculosis by intoxication assessed from the levels of low- and middle-mass substances in blood plasma and red cells. 44 children were examined: 12 children infected with M.tuberculosis, 15 children with active tuberculosis of intrathoracic lymph node tuberculosis, 17 children treated for this disease by routine methods. Higher levels of the above substances were found in children with specific active process. Etiopathogenetic treatment for at least 4 months led to reduction of intoxication which, however, did not reach control concentrations.