Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Head motion during positron emission tomography: is it significant?

U E Ruttimann1, P J Andreason, D Rio

  • 1Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-1256, USA.

Psychiatry Research
|May 31, 1995
PubMed
Summary

Minimizing head motion during positron emission tomography (PET) scans is crucial for accurately detecting brain function differences. Even slight head movements significantly impact metabolic measurements, highlighting the need for motion correction techniques.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intensity-adaptive segmentation of single-echo T1-weighted magnetic resonance images.

Human brain mapping·2010
Same author

A pyramid approach to subpixel registration based on intensity.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2008
Same author

Certainty and mortality prediction in critically ill children.

Journal of medical ethics·2004
Same author

Relevance of diagnostic diversity and patient volumes for quality and length of stay in pediatric intensive care units.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2003
Same author

Long-stay patients in the pediatric intensive care unit.

Critical care medicine·2001
Same author

The impact of prematurity: a perspective of pediatric intensive care units.

Critical care medicine·2001

Area of Science:

  • Neuroimaging
  • Medical Physics
  • Brain Function Analysis

Background:

  • Accurate detection of local brain function differences using positron emission tomography (PET) requires minimizing interscan head motion.
  • PET imaging is sensitive to subtle changes in brain activity under varying stimulation states.

Purpose of the Study:

  • To quantify head motion during prolonged PET scans.
  • To assess the impact of head motion on the detection of local brain function differences.
  • To evaluate the effectiveness of motion restriction systems.

Main Methods:

  • Measured head motion using an optical lever system during 130-minute PET scans in 15 subjects.
  • Subjects were part of a dual-dose injection study with a face-mask restraint system.

Related Experiment Videos

  • Analyzed rotations in sagittal and coronal planes.

    • Main Results:

    • Despite motion restriction, significant head rotations occurred (up to 4.1° sagittal, 2.4° coronal).
    • These movements substantially influenced the measured means and variances of local metabolic differences between stimulation states.
    • The face-mask restraint system did not fully eliminate motion.

    Conclusions:

    • Head motion is a significant confounder in PET studies measuring brain function differences.
    • Retrospective digital slice realignment or real-time motion correction is essential for accurate PET data analysis.
    • Motion correction strategies are vital for enhancing the sensitivity and reliability of neuroimaging findings.