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Pancreas transplantation

R J Stratta1, R J Taylor, J L Larsen

  • 1Department of Surgery, University of Nebraska Medical Center, Omaha 68198-3280, USA.

Renal Failure
|July 1, 1995
PubMed
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Pancreas transplantation offers a chance for insulin independence in diabetes mellitus patients. While successful, it requires lifelong immunosuppression, and long-term effects on diabetic complications require further study.

Area of Science:

  • Endocrinology
  • Nephrology
  • Transplant Surgery

Background:

  • Vascularized pancreas transplantation is increasingly used for diabetes mellitus treatment.
  • Over 6000 pancreas transplants were performed globally by 1994, with most being combined pancreas-kidney procedures.

Purpose of the Study:

  • To evaluate the role and outcomes of vascularized pancreas transplantation in managing diabetes mellitus.
  • To assess the short-term benefits and long-term uncertainties of pancreas transplantation.

Main Methods:

  • Review of worldwide pancreas transplant data up to 1994.
  • Analysis of patient and graft survival rates.
  • Assessment of post-transplant metabolic state and immunosuppression requirements.

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Main Results:

  • 1-year patient survival rates exceed 90%.
  • 1-year graft survival (insulin independence) exceeds 70%.
  • Successful transplantation leads to euglycemia but necessitates chronic immunosuppression and results in hyperinsulinemia.

Conclusions:

  • Pancreas transplantation is a viable option for selected diabetic patients, especially when combined with kidney transplantation.
  • Short-term benefits include improved quality of life and potential prevention of diabetic morbidity.
  • Long-term effects of hyperinsulinemia and immunosuppression on diabetic complications warrant further investigation.