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Related Experiment Videos

[Course of peripheral arterial diseases]

M Zanocchi1, I Bergoglio, R Gallo

  • 1Istituto di Medicina e Chirurgia Geriatrica, Università, Ospedale S. Giovanni Battista e della Città di Torino, Sede Molinette.

Recenti Progressi in Medicina
|September 1, 1995
PubMed
Summary

Peripheral arterial disease (PAD) significantly increases cardiovascular mortality risk. Early detection and severity assessment using ankle-arm pressure ratio are crucial for prognosis.

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Area of Science:

  • Vascular Medicine
  • Cardiovascular Epidemiology
  • Diagnostic Imaging

Background:

  • Peripheral arterial disease (PAD) affects a significant portion of the population.
  • The long-term prognosis and mortality associated with PAD require further investigation.
  • Doppler evaluation is a key diagnostic tool for suspect peripheral arterial disease.

Purpose of the Study:

  • To assess the long-term outcomes and mortality in patients with peripheral arterial disease.
  • To identify factors associated with increased mortality in PAD patients.
  • To evaluate the prognostic value of the ankle-arm pressure ratio in PAD.

Main Methods:

  • Prospective cohort study involving 230 patients initially assessed for PAD using Doppler evaluation.
  • Follow-up of 215 patients (95 with PAD, 120 without) over a 10-year period.

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  • Analysis of mortality causes and correlation with clinical factors including ankle-arm pressure ratio and carotid bruit.

    • Main Results:

    • Patients with PAD had a significantly higher mortality rate (49.5%) compared to those without (13.3%).
    • Age, severity of PAD (ankle-arm pressure ratio), and presence of carotid bruit were associated with increased mortality.
    • Worsening intermittent claudication occurred in 52.1% of PAD patients, with 18.6% progressing to a higher Fontaine classification.

    Conclusions:

    • Peripheral arterial disease is associated with a high risk of cardiovascular mortality and should not be underestimated.
    • The ankle-arm pressure ratio is a valuable tool for defining PAD severity and serves as a valid prognostic criterion.
    • Early identification and management of PAD are essential for improving patient outcomes and reducing mortality.