Related Experiment Video
Updated: Aug 17, 2026

Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane
Published on: April 12, 2018
Reticular pseudodrusen. A risk factor in age-related maculopathy
J J Arnold1, S H Sarks, M C Killingsworth
1Department of Ophthalmology, Eye University Clinic of Creteil, France.
Background:
Reticular pseudodrusen refer to a yellow interlacing network 125 microns to 250 microns wide appearing first in the superior outer macula and then extending circumferentially and beyond. Unlike true drusen, they do not fluoresce on fluorescein or indocyanine green angiography, and are best seen in red-free light or with the He-Ne laser of the scanning laser ophthalmoscope.
Methods:
One hundred patients have been seen in our retinal practice with this clinical feature in the past 3 years.
Results:
All had some manifestation of age-related maculopathy (ARM), and 66% had or subsequently developed subretinal new vessels in one or both eyes. The appearance is attributed to changes in the choroid.
Conclusions:
Reticular pseudodrusen are an easily recognizable clinical sign, and may be an important risk factor for choroidal neovascularization in ARM.
More Related Videos
Related Concept Videos
Photoreceptors and Visual Pathways
Diabetic Retinopathy

