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Selection of women at high risk of breast cancer using two lifestyle markers: a case control study
Objective:
To select a population of women with high risk of invasive breast cancer by using two markers of high risk lifestyle--age at first delivery > = 25 and daily alcohol intake > = 7 g.
Design:
Case control study based on a structural interview.
Setting:
Two general practices in Copenhagen, Denmark.
Participants:
30 patients with invasive breast cancer and 30 age-matched controls.
Main Outcome Measure:
The combined selection power of the two markers of high risk lifestyle.
Results:
The combined selection power of the two markers was significant (P < 0.025, odds ratio 4.3, 95% CI 1.2-15.6).
Conclusion:
Using these markers it may be possible to select about 80% of all cases of invasive breast cancer in a high risk group comprising only 49% of the female population. This could be of importance for mammography screening; rather than unselectively screening all women in a given age bracket, it might be preferable selectively to screen only the high risk group.