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Use of photodynamic therapy for the management of pleural malignancies
1Thoracic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Abstract:
Photodynamic therapy (PDT) is a surface oriented, locally cytotoxic intervention being investigated for oncologic therapy. Surfaces such as the pleura or the peritoneum are frequently involved with primary or metastatic cancer, and the chance for cure in such situations is low due to the inability to eradicate all the disease. A series of investigations have been performed at the National Cancer Institute since 1985 studying the possible use of PDT for large cavity treatment. This report details evolution of the methodology, toxicity, and overall feasibility of the delivery of intrapleural PDT to patients after debulking of primary and malignant chest neoplasms, with an emphasis on malignant pleural mesothelioma. These investigations have culminated in an ongoing Phase III trial to define the efficacy of intrapleural PDT.
Insights
Photodynamic therapy (PDT) offers a localized cancer treatment for large cavities. Intrapleural PDT is being evaluated for malignant pleural mesothelioma, with ongoing trials to confirm its effectiveness.
Area of Science:
- Oncology
- Photodynamic Therapy
Background:
- Malignant tumors on surfaces like the pleura or peritoneum have a low cure rate.
- Eradicating all cancer cells in these large cavities is challenging.
Purpose of the Study:
- To investigate the use of photodynamic therapy (PDT) for treating large cavities, specifically intrapleural space.
- To detail the evolution of methodology, toxicity, and feasibility of intrapleural PDT for chest neoplasms, focusing on malignant pleural mesothelioma.
Main Methods:
- The study details investigations conducted at the National Cancer Institute since 1985.
- Methodology, toxicity, and feasibility of intrapleural PDT delivery after debulking are described.
Main Results:
- Evolutions in PDT methodology have been detailed.
- Toxicity and feasibility of intrapleural PDT have been assessed.
Conclusions:
- Intrapleural PDT is a feasible, locally cytotoxic intervention for large cavity treatment.
- A Phase III trial is underway to establish the efficacy of intrapleural PDT for malignant pleural mesothelioma.