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Updated: May 2, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Basic principles of pharmacokinetics
L Z Benet1, P Zia-Amirhosseini
1Department of Pharmacy, University of California, San Francisco 94143-0446, USA.
Abstract:
Pharmacokinetics may be defined as what the body does to a drug. It deals with the absorption, distribution, and elimination of drugs but also has utility in evaluating the time course of environmental (exogenous) toxicologic agents as well as endogenous compounds. An understanding of 4 fundamental pharmacokinetic parameters will give the toxicologic pathologist a strong basis from which to appreciate how pharmacokinetics may be useful. These parameters are clearance, volume of distribution, half-life, and bioavailability.
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