[Acute kidney failure in tubular necrosis]

Tubular necrosis is the most frequent hospital-acquired cause of acute renal failure from renal origin. The two main factors leading to tubular necrosis are hemodynamic perturbations and use of nephrotoxic agents. There is recently a growing number of reports on tubular necrosis associated with a non traumatic rhabdomyolysis. In 60-70% of the cases, more than one contributing factor can be identified. In the majority of the patients who developed a transient postoperative acute renal failure, co-morbid factors such as diabetes, hypertension or major cardiovascular problems, are present. Acute renal failure increases the mortality by factors from 2-7. Therefore prevention and (or) early correction of the factors leading to tubular necrosis are of great importance.