Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Possibilities for quality assurance of reference intervals

T Koivula1

  • 1Department of Clinical Chemistry, Tampere University Hospital, Finland.

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
|January 1, 1995
PubMed
Summary

Clinical laboratories often neglect external quality assurance (EQA) results for analytical accuracy. Implementing valid, laboratory-specific reference values is crucial, and EQA methods can validate these limits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular characterisation of Mycobacterium bovis isolates from cattle carcases at a city slaughterhouse in Uganda.

The Veterinary record·2009
Same author

Mycobacterium tuberculosis Uganda genotype is the predominant cause of TB in Kampala, Uganda.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2008
Same author

Outbreak of Mycobacterium tuberculosis infection among captive Asian elephants in a Swedish zoo.

The Veterinary record·2005
Same author

Means to improve the effect of in situ bioremediation of contaminated soil: an overview of novel approaches.

Environmental pollution (Barking, Essex : 1987)·2004
Same author

Promoter polymorphism of IL-10 and severity of multiple sclerosis.

Acta neurologica Scandinavica·2003
Same author

Methylenetetrahydrofolate reductase gene C677T mutation is related to the defects in the internal elastic lamina of the artery wall.

European journal of clinical investigation·2003

Area of Science:

  • Clinical Laboratory Science
  • Analytical Chemistry
  • Quality Management in Healthcare

Background:

  • External quality assurance (EQA) is widely adopted by clinical laboratories.
  • EQA results are infrequently used to control analytical accuracy and level.
  • Many labs lack valid, internally-derived reference intervals, using literature or other labs' values instead.

Purpose of the Study:

  • To highlight the underutilization of EQA data for analytical accuracy control.
  • To emphasize the necessity of laboratory-specific, valid reference values.
  • To propose extending EQA techniques for validating laboratory reference limits.

Main Methods:

  • Review of current practices in clinical laboratory EQA participation.
  • Analysis of the gap between EQA participation and its application to analytical accuracy.
  • Exploration of EQA methodologies for reference limit validation.

Main Results:

  • EQA participation does not consistently translate to improved analytical accuracy control.
  • Non-adherence to recommendations for determining reference intervals is common.
  • Existing EQA frameworks offer potential for validating laboratory-specific reference limits.

Conclusions:

  • Effective utilization of EQA data for analytical accuracy requires a paradigm shift.
  • Laboratories must prioritize establishing and validating their own reference intervals.
  • EQA techniques can be adapted to ensure the reliability of laboratory reference limits.

Related Experiment Videos