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Related Experiment Videos

Estimation of reference change limits using patient data

V Kairisto1, T Kouri, A Virtanen

  • 1Department of Clinical Chemistry, University of Turku, Finland.

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
|January 1, 1995
PubMed
Summary
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This study presents two methods for calculating reference change limits from patient data, utilizing hospital databases or indirect estimations. A new software, GraphROC for Windows, implements these methods for improved clinical interpretation.

Area of Science:

  • Clinical Chemistry
  • Medical Informatics
  • Biostatistics

Background:

  • Establishing reliable reference change limits is crucial for interpreting patient test results over time.
  • Existing methods may face limitations due to insufficient or unreliable hospital database information.

Purpose of the Study:

  • To describe two distinct approaches for deriving reference change limits from patient data.
  • To introduce a software tool, GraphROC for Windows, that incorporates these methods.

Main Methods:

  • Direct method: Utilizes hospital database information for reference group selection.
  • Indirect method: Applied when database information is insufficient, allowing for rough estimates.
  • Incorporation of time between specimen collections as a classifying factor.

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Main Results:

  • The study details the direct and indirect methods for calculating reference change limits.
  • GraphROC for Windows software is presented as a tool for implementing these estimations.
  • Guidance is provided on selecting appropriate methods based on data availability and heterogeneity.

Conclusions:

  • Both direct and indirect methods offer valuable approaches for determining reference change limits.
  • Time series analysis is recommended for clinical interpretation when multiple previous results and heterogeneous within-subject variances are present.
  • The GraphROC software facilitates the practical application of these methods in clinical settings.